Non-Invasive Tumor-Naive Minimal Residual Disease Detection of Liver Cancer by Incorporating Circulating Tumor DNA Features and Alpha-Fetoprotein: A Prospective Study.

ABSTRACT:

Background and purpose

Liver cancer has a high recurrence rate of 50%~70% for early-stage patients. Minimal residual disease (MRD) is strongly linked to liver cancer early recurrence. Identifying MRD through reliable prognostic biomarkers, such as circulating tumor DNA (ctDNA), could significantly benefit these patients by enabling timely intervention and improved outcomes.

Materials and methods

A prospective study enrolled 32 liver cancer patients undergoing radical surgery. Peripheral blood samples (8 mL) were collected before and after surgery. In this study, we expanded upon our previously developed multi-omics assay, initially designed for liver cancer early detection by calculating a cancer signal score (P_HCC), to determine the MRD status (named SeekInCure).

SUBMITTER: Ren Q 

PROVIDER: S-EPMC11660314 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature