The correlation between immune cells and endometriosis: a bidirectional two-sample mendelian randomization study.

ABSTRACT:

Objectives

Endometriosis (EM), a prevalent estrogen-dependent inflammatory disorder affecting women of reproductive age, is characterized by the presence of endometrial-like tissue outside the uterus, resulting in pelvic scarring, pain, and infertility. Although the pathogenesis of EM remains poorly understood, there is growing evidence suggesting the involvement of the immune system in its etiology, pathophysiology, and associated morbidities such as pain, infertility, and adverse pregnancy outcomes. While previous studies have indicated a close relationship between the immune system and EM, the specific underlying mechanism remains incompletely elucidated.

Methods

Through the utilization of publicly available genetic data, a two-sample Mendelian randomization (MR) analysis

SUBMITTER: Pan L 

PROVIDER: S-EPMC11660437 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature