Impact of galectin-3 on neurotrophic factor expression by PCR array: potential implications for the human cornea.

ABSTRACT: The cornea is densely innervated to maintain the integrity of the ocular surface, facilitating functions such as sensation and tear production. Following damage, alterations in the corneal microenvironment can profoundly affect its innervation, potentially impairing healing and sensory perception. One protein frequently upregulated at the ocular surface following tissue damage is galectin-3, but its contribution to corneal nerve regeneration remains unclear. Here, we sought to delineate the role of galectin-3 in regulating the expression of neurotrophic factors by different human cell types. Using a pathway-focused PCR array, we first evaluated the expression of neurotrophic factors in primary cultures of human corneal epithelial cells and fibroblasts. We found that these cell types contri

SUBMITTER: Woodward AM 

PROVIDER: S-EPMC11660451 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature