Cognitive decline profiles associated with lewy pathology in the context of Alzheimer's disease neuropathologic change.

ABSTRACT:

Background

Alzheimer's disease neuropathologic change (ADNC) and Lewy pathology (LP) often coexist in cognitively impaired individuals. These pathologies' relative distribution and severity may modify these individuals' clinical presentation, cognitive profile, and prognosis. Therefore, we examined the contributions of LP and concomitant ADNC to disease survival and profiles of cognitive decline in preclinical and clinical stages in a large neuropathologically diagnosed group.

Methods

We evaluated 597 participants with LP and 491 participants with intermediate/high ADNC in the absence of LP from the National Alzheimer Coordinating Center (NACC) database. At baseline, 237 participants were cognitively normal (CN), 255 were diagnosed with mild cognitive impairment (MCI), and 5

SUBMITTER: Toledo JB 

PROVIDER: S-EPMC11660495 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature