Hemoglobin A1c and abdominal obesity as predictors of diabetes and ASCVD in individuals with prediabetes in UK Biobank: a prospective observational study.

ABSTRACT:

Objectives

Whether "prediabetes" merits particular clinical attention beyond the management of associated risk factors is controversial, particularly given the expansion of the definition of prediabetes from HbA1c 6.0-6.4% to 5.7-6.4%. Accordingly, we compared the risk of atherosclerotic cardiovascular disease (ASCVD) and type II diabetes mellitus (DM) risk in male and female participants with prediabetes and HbA1c 5.7-6.0% (low) versus 6.1-6.4% (high) to examine whether preventive recommendations should prioritize treating blood sugar or obesity, the major determinants of risk of DM versus other causes of ASCVD, such as lipids and blood pressure.

Research design and methods

10-year risks of ASCVD and DM risk were determined separately in 296,470 women and men, age 40-73, fr

SUBMITTER: Pencina KM 

PROVIDER: S-EPMC11660550 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature