Effects of liraglutide on abdominal fat distribution and glucose metabolism in Chinese subjects with obesity.

ABSTRACT:

Aims

To observe the effects of liraglutide on abdominal fat distribution in Chinese subjects with obesity in 12 weeks, and further to explore the correlation between abdominal fat content and glucose metabolism after monotherapy.

Methods

This study recruited 71 obese subjects. All the subjects have received liraglutide monotherapy (0.6 mg-1.8 mg/d) for 12 weeks. Clinical assessment, laboratory assays and magnetic resonance imaging (MRI) examination were accessed at baseline and after 12 weeks treatment. MRI was applied to measure abdominal fat distribution, calculated by proton-density fat fraction (PDFF).

Results

After 12 weeks of liraglutide monotherapy, body weight in the obese participants decreased significantly (P < 0.001). Fasting blood glucose (FBG) levels, 2 

SUBMITTER: Du M 

PROVIDER: S-EPMC11660634 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature