Analytical and clinical performance of eight Simoa^® and Lumipulse^® assays for automated measurement of plasma p-tau181 and p-tau217.

ABSTRACT:

Background

Among the Alzheimer's disease (AD) biomarkers measured in blood, phosphorylated forms of tau (p-tau) have been shown to exhibit a particularly high diagnostic potential. Here, we performed a comprehensive method comparison study, followed by evaluation of the diagnostic performance of eight recent plasma p-tau immunoassays targeting different tau phosphorylation sites, different tau fragments, and that are measured by two distinct platforms.

Methods

We enrolled a cohort of 40 patients with AD at the stage of dementia (AD-dem) characterized by positive CSF A + T + profile, and a control group of 40 cognitively healthy participants (Control), to conduct a comprehensive method comparison for three plasma p-tau181 and five plasma p-tau217 assays run on the Simoa^®

SUBMITTER: Wojdala AL 

PROVIDER: S-EPMC11660642 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature