A constitutive heterochromatic region shapes genome organization and impacts gene expression in Neurospora crassa.

ABSTRACT:

Background

Organization of the eukaryotic genome is essential for proper function, including gene expression. In metazoans, chromatin loops and Topologically Associated Domains (TADs) organize genes into transcription factories, while chromosomes occupy nuclear territories in which silent heterochromatin is compartmentalized at the nuclear periphery and active euchromatin localizes to the nucleus center. A similar hierarchical organization occurs in the fungus Neurospora crassa where its seven chromosomes form a Rabl conformation typified by heterochromatic centromeres and telomeres independently clustering at the nuclear membrane, while interspersed heterochromatic loci aggregate across Megabases of linear genomic distance to loop chromatin in TAD-like structures. However, the rol

SUBMITTER: Reckard AT 

PROVIDER: S-EPMC11660810 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature