Dietary methionine supplementation promotes mice hematopoiesis after irradiation.

ABSTRACT:

Background

With the increasing risk of nuclear exposure, more attention has been paid to the prevention and treatment of acute radiation syndrome (ARS). Although amino acids are key nutrients involved in hematopoietic regulation, the impacts of amino acids on bone marrow hematopoiesis following irradiation and the associated mechanisms have not been fully elucidated. Hence, it is of paramount importance to study the changes in amino acid metabolism after irradiation and their effects on hematopoiesis as well as the related mechanisms.

Methods

The content of serum amino acids was analyzed using metabolomic sequencing. The survival rate and body weight of the irradiated mice were detected after altering the methionine content in the diet. Extracellular matrix (ECM) protein ana

SUBMITTER: Zhang WW 

PROVIDER: S-EPMC11660814 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature