Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice.

ABSTRACT:

Background

Primordial follicle activation is vital for the reproduction of women with advanced age and premature ovarian insufficiency (POI). But there is a lack of effective and safe therapeutic options to activate their primordial follicles in vivo. Berberine (BBR) possesses multiple pharmacological properties, but its impact on primordial follicle activation remains unclear.

Methods

The role of BBR on primordial activation was investigated by neonatal mouse ovary culture and intraperitoneal injection, and by human ovarian fragment culture. Furthermore, the effect of BBR on the quantity of ovulated oocytes was investigated by the intragastric administration of aged mice.

Results

BBR in vitro culture and in vivo intraperitoneal injection significantly increased growi

SUBMITTER: Liu S 

PROVIDER: S-EPMC11660874 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature