Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study.

ABSTRACT:

Background

Mood instability, characterized by sudden and unpredictable mood shifts, is prevalent in psychiatric disorders and as a personality trait. Its association with gastrointestinal diseases has been recognized but remains poorly understood in terms of causality.

Methods

This study aims to investigate the causal relationship between mood instability and a spectrum of gastrointestinal diseases by univariable and multivariable mendelian randomization analysis. The exposure and outcome data were retrieved from the IEU open GWAS database, the UK biobank and the FinnGen study. Instrumental variables were selected to meet relevance, independence, and exclusion restriction criteria. GWAS datasets for mood instability and 28 gastrointestinal diseases were utilized, incorporati

SUBMITTER: Liu RL 

PROVIDER: S-EPMC11660901 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature