Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration.

ABSTRACT: Cardiac regeneration involves the interplay of complex interactions between many different cell types, including cardiomyocytes. The exact mechanism that enables cardiomyocytes to undergo dedifferentiation and proliferation to replace lost cells has been intensely studied. Here we report a single nuclear RNA sequencing profile of the injured zebrafish heart and identify distinct cardiomyocyte populations in the injured heart. These cardiomyocyte populations have diverse functions, including stress response, myofibril assembly, proliferation and contraction. The contracting cardiomyocyte population also involves the activation of maturation pathways as an early response to injury. This intriguing finding suggests that constant maintenance of a distinctive terminally differentiated cardiomyo

SUBMITTER: Forman-Rubinsky R 

PROVIDER: S-EPMC11661073 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature