Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics.

ABSTRACT:

Background

Exposure to endocrine-disrupting chemicals (EDCs), such as bisphenol A (BPA), disrupts reproduction across generations. Germ cell epigenetic alterations are proposed to bridge transgenerational reproductive defects resulting from EDCs. Previously, we have shown that prenatal exposure to environmentally relevant doses of BPA or its substitute, BPS, caused transgenerationally maintained reproductive impairments associated with neonatal spermatogonial epigenetic changes in male mice. While epigenetic alterations in germ cells can lead to transgenerational phenotypic variations, the mechanisms sustaining these changes across generations remain unclear.

Objectives

This study aimed to systematically elucidate the mechanism of transgenerational inherence by prenatal BPA

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11661074 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature