Identification of diversity-generating retroelements in host-associated and environmental genomes: prevalence, diversity, and roles.

ABSTRACT:

Background

The diversity-generating retroelements (DGRs) are a family of genetic elements that can produce mutations in target genes often related to ligand-binding functions, which possess a C-type lectin (CLec) domain that tolerates massive variations. They were first identified in viruses, then in bacteria and archaea from human-associated and environmental genomes. This DGR mechanism represents a fast adaptation of organisms to ever- changing environments. However, their existence, phylogenetic and structural diversity, and functions in a wide range of environments are largely unknown.

Results

Here we present a study of DGR systems based on metagenome-assembled genomes (MAGs) from host-associated, aquatic, terrestrial and engineered environments. In total, we identified

SUBMITTER: Carrasco-Villanueva M 

PROVIDER: S-EPMC11661182 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature