Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kedougou, Senegal.

ABSTRACT:

Background

The emergence of pfhrp2/3-deleted parasites threatens histidine-rich protein 2 (HRP2)-based malaria rapid diagnostic test (RDT) performance. RDTs targeting Plasmodium falciparum (Pf) lactate dehydrogenase (LDH) may address current product limitations and improve case management.

Objectives

To evaluate the performance and usability of three LDH-based RDTs in febrile patients.

Methods

A cross-sectional diagnostic accuracy study was conducted in Kédougou, Senegal. Capillary blood was tested using the SD Bioline Ag Pf (#05FK50) and three LDH-based RDTs: BIOCREDIT Malaria Ag Pf (pLDH), BIOCREDIT Pf (pLDH/HRPII), and BIOCREDIT Pf/Pv (pLDH/pLDH) (Rapigen Inc., Republic of Korea). Venous blood was collected to repeat the BIOCREDIT RDTs and cond

SUBMITTER: Sambe BS 

PROVIDER: S-EPMC11661343 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature