Improving survival models in healthcare: a novel matching approach.

ABSTRACT: We present, to our knowledge, the first methodological study aimed at enhancing the prognostic power of Cox regression models, widely used in survival analysis, through optimized data selection. Our approach employs a novel two-stage mechanism: by framing the prognostic stratum matching problem intuitively, we select prognostically representative patient observations to create a more balanced training set. This enables the model to assign equal attention to distinct prognostic subgroups. We demonstrate the methodology using an observational dataset of 1,799 patients with resected colorectal cancer liver metastases, 1,197 of whom received adjuvant chemotherapy and 602 who did not. In our study, as is current standard practice, the comparator was training prognostic models on the entire coho

SUBMITTER: Bertsimas D 

PROVIDER: S-EPMC11661418 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature