Testosterone Effects on Short-Term Physical, Hormonal, and Neurodevelopmental Outcomes in Infants with 47,XXY/Klinefelter Syndrome: The TESTO Randomized Controlled Trial.

ABSTRACT:

Context

47,XXY/Klinefelter syndrome (XXY) is associated with impaired testicular function and differences in physical growth, metabolism, and neurodevelopment. Clinical features of XXY may be attributable to inadequate testosterone during the mini-puberty period of infancy.

Objective

We tested the hypothesis that exogenous testosterone treatment positively effects short-term physical, hormonal, and neurodevelopmental outcomes in infants with XXY.

Design

Double-blind randomized controlled trial, 2017-2021.

Setting

US tertiary care pediatric hospital.

Patients

Infants 30-90 days of age with prenatally identified, non-mosaic 47,XXY (n=71).

Intervention

Testosterone cypionate 25mg intramuscular injections every 4 weeks for 3 doses.

Main outcome mea

SUBMITTER: Davis S 

PROVIDER: S-EPMC11661422 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature