Understanding the Effectiveness of Water, Sanitation, and Hygiene Interventions: A Counterfactual Simulation Approach to Generalizing the Outcomes of Intervention Trials.

ABSTRACT:

Background

While water, sanitation, and hygiene (WASH) interventions can reduce diarrheal disease, many large-scale trials have not found the expected health gains for young children in low-resource settings. Evidence-based guidance is needed to improve interventions and remove barriers to diarrheal disease reduction.

Objectives

We aimed to estimate how sensitive WASH intervention effectiveness was to underlying contextual and intervention factors in the WASH Benefits (WASH-B) Bangladesh cluster-randomized controlled trial.

Methods

The investigators measured diarrheal prevalence in children enrolled in the WASH-B trial at three time points approximately 1 year apart (n=17,187 observations). We developed a susceptible-infectious-susceptible model with transmission acro

SUBMITTER: Brouwer AF 

PROVIDER: S-EPMC11661469 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature