Identification and evaluation of a serum microRNA panel to diagnose colorectal cancer patients.

ABSTRACT: Screening plays a crucial role in the early detection of colorectal cancer, greatly reducing mortality rates. The objective of this study was to identify a non-invasive diagnostic method utilizing serum microRNA expression for the diagnosis of colorectal cancer patients. The study consisted of three stages. In the first stage, 129 patients with colorectal cancer and 129 normal subjects were recruited as the training set for the development of a blood miRNA panel. The second stage involved recruiting 200 patients from each group as the validation cohort. Finally, a blinded study was conducted in the third stage, with 260 patients recruited to determine the predictive value of our miRNA panel. Serum samples were prospectively collected from colorectal cancer patients and normal subjects betw

SUBMITTER: Ng L 

PROVIDER: S-EPMC11661512 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature