Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure.

ABSTRACT:

Introduction

The aging process is intricately linked to alterations in cellular and tissue structures, with the respiratory system being particularly susceptible to age-related changes. Therefore, this study aimed to profile the activity of proteases using activity-based probes in lung tissues of old and young rats, focusing on the expression levels of different, in particular cathepsins G and X and matrix Metalloproteinases (MMPs). Additionally, the impact on extracellular matrix (ECM) components, particularly fibronectin, in relation to age-related histological and ultrastructural changes in lung tissues was investigated.

Materials and methods

Lung tissues from old and young rats were subjected to activity-based probe profiling to assess the activity of different proteases

SUBMITTER: Aufy M 

PROVIDER: S-EPMC11661583 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature