Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction.

ABSTRACT:

Background

Gene-environment interaction (G × E) is likely an important influence shaping individual differences in alcohol misuse (AM), yet it has not been extensively studied in molecular genetic research. In this study, we use a series of genome-wide gene-environment interaction (GWEIS) and in silico annotation methods with the aim of improving gene identification and biological understanding of AM.

Methods

We carried out GWEIS for four AM phenotypes in the large UK Biobank sample (N = 360,314), with trauma exposure and socioeconomic status (SES) as moderators of the genetic effects. Exploratory analyses compared stratified genome-wide association (GWAS) and GWEIS modeling approaches. We applied functional annotation, gene- and gene-set enrichment, and polygenic score anal

SUBMITTER: Savage JE 

PROVIDER: S-EPMC11661684 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature