Manual single lumen alternating micro-batch dialysis achieves reliable clearance via diffusion.

ABSTRACT:

Background

Acute kidney injury is a cause of preventable deaths in low resource settings due to lack of dialysis access and cost. A manual single lumen alternating micro-batch (mSLAMB) dialysis technique performs kidney replacement therapy using single lumen access, low-cost bags/tubing, intravenous fluids, and a filter without electricity, a battery, or a pump. We propose a protocol whereby mSLAMB can perform diffusive clearance simply and efficiently to bring dialysis to underserved populations.

Methods

Expired packed red blood cells mixed with crystalloid solution were spiked with urea and anticoagulated with heparin. A Static diffusion Technique (with short flushes of fluid before each filter pass) was compared to a Dynamic diffusion Technique (with fluid running through

SUBMITTER: Ceschia G 

PROVIDER: S-EPMC11661701 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature