Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam.

ABSTRACT:

Background

After pneumococcal disease and colonization have been controlled through vaccination campaigns, a reduced pneumococcal conjugate vaccine (PCV) schedule may be sufficient to sustain that control at reduced costs.

Methods

We investigated whether a single primary dose and booster dose (1p+1) of the 10-valent PCV (PCV10) would be noninferior to alternative dose schedules in sustaining control of carriage of pneumococcal serotypes included in the vaccine. In Nha Trang, Vietnam, an area in which PCV had not been used previously, a PCV10 catch-up campaign was conducted in which the vaccine was offered to children younger than 3 years of age, after which a cluster-randomized trial was conducted in which children received PCV10 at 2, 3, and 4 months of age (3p+0 group); at

SUBMITTER: Yoshida LM 

PROVIDER: S-EPMC11661757 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature