Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation.

ABSTRACT:

Background

Patients requiring extracorporeal life support (ECLS) support post-Norwood operation constitute an extremely high-risk group.

Materials and methods

We retrospectively aimed to evaluate the relationship of hyperoxia with mortality and other clinical outcomes in patients who required ECLS following Norwood operation between January/2010 and December/2020 in a large volume center.

Results

During the study period 65 patients required ECLS post-Norwood. Using receiver operating characteristic (ROC) curve analysis, mean PaO₂ of 182 mmHg in the first 48-hour on ECLS was determined to have the optimal discriminatory ability for mortality (sensitivity 68%, specificity 70%). Of the 65 patients, 52% had PaO₂ > 182 mmHg and were designated as hype

SUBMITTER: Beshish AG 

PROVIDER: S-EPMC11661777 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature