Interaction of milrinone with extracorporeal life support.

ABSTRACT:

Background

Milrinone is commonly prescribed to critically ill patients who need extracorporeal life support such as extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT). Currently, the effect of ECMO and CRRT on the disposition of milrinone is unknown.

Methods

Ex vivo ECMO and CRRT circuits were primed with human blood and then dosed with milrinone to study drug extraction by the circuits. Milrinone percent recovery over time was calculated to determine circuit component interaction with milrinone.

Results

Milrinone did not exhibit measurable interactions with the ECMO circuit, however, CRRT cleared 99% of milrinone from the experimental circuit within the first 2 hours.

Conclusion

Milrinone dosing adjustments are likely re

SUBMITTER: Whelan AJ 

PROVIDER: S-EPMC11661780 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature