The effect of combining antibiotics on resistance: A systematic review and meta-analysis.

ABSTRACT:

Background

Under which conditions antibiotic combination therapy decelerates rather than accelerates resistance evolution is not well understood. We examined the effect of combining antibiotics on within-patient resistance development across various bacterial pathogens and antibiotics.

Methods

We searched CENTRAL, EMBASE, and PubMed for (quasi)-randomised controlled trials (RCTs) published from database inception to 24 November 2022. Trials comparing antibiotic treatments with different numbers of antibiotics were included. Patients were considered to have acquired resistance if, at the follow-up culture, a resistant bacterium (as defined by the study authors) was detected that had not been present in the baseline culture. We combined results using a random effects model and

SUBMITTER: Siedentop B 

PROVIDER: S-EPMC11661791 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature