Spray-dried cyclophosphamide-loaded polyhydroxyalkanoate microparticles: design and characterization.

ABSTRACT:

Background and purpose

Cyclophosphamide (CP) is a widely used antitumor and immunosuppressive drug, but it is highly cytotoxic and has carcinogenic and teratogenic potential. To reduce adverse effects of CP therapy and the frequency of its administration, the microencapsulation of CP into biodegradable polymeric matrices can be performed. However, according to the literature, only a few polymers were found suitable to encapsulate CP and achieve its' sustained release.

Experimental approach

In this research, spray-dried cyclophosphamide-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microparticles were prepared and characterized in terms of their average hydrodynamic diameter, polydispersity index, surface morphology, zeta potential, encapsulation efficiency, drug

SUBMITTER: Lipaikin S 

PROVIDER: S-EPMC11661805 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature