Causal relationships between skin microbiome and pathological scars: a bidirectional mendelian randomization study.

ABSTRACT: Skin bacteria infection could be a potential risk factor on wound scar formation, yet the specifics of this relationship are not fully understood. This research investigates the causal relationships between specific skin microbiome and these diseases by using bidirectional Mendelian randomization (MR). This study employed a bidirectional MR analysis using genome-wide association study (GWAS) data to analyze the associations between skin microbiome and pathological scar. Single nucleotide polymorphisms (SNPs) served as instrumental variables (IVs) in MR methods, including inverse variance weighted (IVW), and MR Egger. The IVW analysis suggested a significant relationship between specific skin microbiome and pathlogical scars. Actinomycetales_Sebaceous, Proteobacteria_Sebaceous, ASV072[Parac

SUBMITTER: Zhu W 

PROVIDER: S-EPMC11662043 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature