Potential benefits of neoadjuvant radiotherapy prior to "en bloc" compartmental resection of pure retroperitoneal liposarcomas.

ABSTRACT: Retroperitoneal liposarcomas(RPL) are rare malignant tumors, accounting for approximately 15% of soft tissue sarcomas and 0.07-0.2% of all cancers. The annual incidence is 0.5 to 1 per 100,000 individuals. Surgical resection is the only curative option, but recurrence rates are high, and the role of neoadjuvant radiotherapy(NRT) remains uncertain. This study aimed to assess the impact of preoperative NRT on overall survival(OS) and recurrence-free survival(RFS) in RPL patients undergoing compartmental resection, while identifying prognostic factors. A retrospective monocentric review of 94 patients with confirmed RPL treated between 2008 and 2022 was conducted. Forty-six patients received NRT, while 48 underwent surgery alone. Data on preoperative, intraoperative, and postoperative variabl

SUBMITTER: Mercier J 

PROVIDER: S-EPMC11662060 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature