Associations between brain network, puberty, and behaviors in boys with Klinefelter syndrome.

ABSTRACT:

Background

Klinefelter syndrome (KS), also referred to as XXY syndrome, is a significant but inadequately studied risk factor for neuropsychiatric disability. Whether alterations in functional brain connectivity or pubertal delays are associated with aberrant cognitive-behavioral outcomes in individuals with KS is largely unknown. In this observational study, we investigated KS-related alterations in the resting-state brain network, testosterone level, and cognitive-behavioral impairment in adolescents with Klinefelter syndrome.

Methods

We recruited 46 boys with KS, ages 8 to 17 years, and 51 age-matched typically developing (TD) boys. All participants underwent resting-state functional magnetic resonance imaging scans, pubertal, and cognitive-behavioral assessments. Resting

SUBMITTER: Li R 

PROVIDER: S-EPMC11662083 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature