The chemotactic response of Caenorhabditis elegans represents a promising tool for the early detection of cancer.

ABSTRACT: The nematode Caenorhabditis elegans, with its highly sensitive olfactory system, has emerged as a promising tool for testing chemotaxis. In the field of cancer diagnostics, there is a growing interest in the development of non-invasive screening methods for the detection of volatile organic compounds in a patient's urine. The objective of this study was to contribute to the existing body of knowledge by evaluating the ability of a Caenorhabditis elegans-based chemotaxis assay to discriminate between urine samples from healthy individuals and patients diagnosed with breast or colon cancer. Following synchronization of the developmental stages of C. elegans, nematodes were exposed to the urine of cancer patients and healthy individuals. Subsequently, chemotactic indices were calculated for e

SUBMITTER: Kaiglova A 

PROVIDER: S-EPMC11662101 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature