Phytochemical composition, in vitro cytotoxicity and in silico ADME/Tox analysis of the active compounds of <i>Oxalis latifolia</i> Kunth. extracts with promising anticancer potential.

ABSTRACT: This study investigated the anticancer phytocompounds in leaf extracts of Oxalis latifolia Kunth. Quantitative analysis of the phytochemical composition showed high levels of primary metabolites: carbohydrates (45.11 ± 2.15 GLE mg/100 mg), proteins (28.13 ± 0.94 BSA mg/100 mg), and amino acids (13.25 ± 1.16 LE mg/100 mg). Ethyl acetate extracts had the highest concentrations of secondary metabolites, including phenolic content (122.52 ± 4.27 GAE mg/100 mg), total flavonoids (91.86 ± 2.65 QE mg/100 mg), and alkaloids (82.18 ± 0.72 COLE mg/100 mg). In addition, strong antioxidant activities were observed in the DPPH^• scavenging assay (IC₅₀ 11.51 ± 2.28 µg/mL), ABTS^·+ radical cation scavenging activity (97.42 ± 7.19 µM TE/g), and FRAP assay (14.34 ± 1.2

SUBMITTER: Vignesh A 

PROVIDER: S-EPMC11662119 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature