Whole exome sequencing revealed new variants and haplotypes associated with monogenic obesity.

ABSTRACT:

Objectives

This study aims to identify new variants and haplotypes associated with monogenic obesity by analyzing known obesity genes in whole exome sequencing (WES) data.

Methods

The monogenic obesity-associated genes were identified by using the National Institutes of Health (NIH) Genetic Testing Registry (GTR) monogenic obesity panels. WES was performed on (n = 49) extremely obese (children under 5 with weight-for-height greater than 3 standard deviations (SD) above the World Health Organization (WHO) Child Growth Standards median) and (n = 50) control nonobese (25 > body mass index (BMI) < 30) subjects without a history of childhood obesity, and also Iranome WES data of healthy subjects (n = 800).

Results

Seventy-four genes were included in WE

SUBMITTER: Gholami M 

PROVIDER: S-EPMC11662120 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature