Impact of molecular classification on prognosis in children and adolescents with spinal ependymoma: Results from the HIT-MED database.

ABSTRACT:

Background

Ependymomas of the spinal cord are rare among children and adolescents, and the individual risk of disease progression is difficult to predict. This study aims to evaluate the prognostic impact of molecular typing on pediatric spinal cord ependymomas.

Methods

Eighty-three patients with spinal ependymomas ≤22 years registered in the HIT-MED database (German brain tumor registry for children, adolescents, and adults with medulloblastoma, ependymoma, pineoblastoma, and CNS-primitive neuroectodermal tumors) between 1992 and 2022 were included. Forty-seven tumors were analyzed by DNA methylation array profiling. In 6 cases, HOXB13 and MYCN proteins were detected as surrogate markers for specific methylation classes. Ten patients had NF2-related schwannomatosis.<

SUBMITTER: Engertsberger L 

PROVIDER: S-EPMC11662162 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature