Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy.

ABSTRACT:

Objectives

The impact of mild autonomous cortisol secretion (MACS) on cognition is incompletely characterized. We aimed to assess cognition in patients with MACS, identify factors associated with lower cognition, and determine the impact of adrenalectomy on cognition.

Methods

We conducted a cross-sectional study (4/2019 to 10/2022) and a longitudinal cohort study (10/2021 to 9/2023) of adults with MACS and referent subjects. Cognition was assessed with National Institute of Health Toolbox Cognition Battery and reported as standardized T scores (adjusted for age, sex, race/ethnicity, and education) for fluid, crystallized, and total composite cognition. Participants were assessed with urine steroid profiling (liquid chromatography-tandem mass spectrometry), frailty index, Bec

SUBMITTER: Saini J 

PROVIDER: S-EPMC11662234 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature