Associations Between Prenatal Vitamin D and Placental Gene Expression.

ABSTRACT:

Background

Vitamin D is a hormone that regulates gene transcription. Prenatal vitamin D has been linked to immune and vascular function in the placenta, a key organ of pregnancy. Transcriptome-wide RNA sequencing can provide a more complete representation of the placental effects of vitamin D.

Objectives

We investigated the association between prenatal vitamin D concentrations and placental gene expression in a large, prospective pregnancy cohort.

Methods

Participants were recruited from Shelby County, TN, United States, in the Conditions Affecting Neurocognitive Development and Learning in Early childhood (CANDLE) study. Vitamin D (plasma total 25-hydroxyvitatmin D, [25(OH)D]) was measured at midpregnancy (16-28 wk) and delivery. RNA was sequenced from placental samp

SUBMITTER: Parenti M 

PROVIDER: S-EPMC11662243 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature