Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19.

ABSTRACT: COVID-19 is characterized by systemic pro-inflammatory shifts with the development of serious alterations in the functioning of the immune system. Investigations of the gene expression changes accompanying the infection state provide insight into the molecular and cellular processes depending on the sickness severity and virus variants. Severe Delta COVID-19 has been characterized by the appearance of a monocyte subset enriched for proinflammatory gene expression signatures and a shift in ligand-receptor interactions. We profiled the chromatin accessibility landscape of 140,000 nuclei in PBMC samples from healthy individuals or individuals with COVID-19. We investigated cis-regulatory elements and identified the core transcription factors governing gene expression in immune cells during CO

SUBMITTER: Akimov VE 

PROVIDER: S-EPMC11662282 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature