Bacteria of the order Burkholderiales are original environmental hosts of type II trimethoprim resistance genes (dfrB).

ABSTRACT: It is consensus that clinically relevant antibiotic resistance genes have their origin in environmental bacteria, including the large pool of primarily benign species. Yet, for the vast majority of acquired antibiotic resistance genes, the original environmental host(s) has not been identified to date. Closing this knowledge gap could improve our understanding of how antimicrobial resistance proliferates in the bacterial domain and shed light on the crucial step of initial resistance gene mobilization in particular. Here, we combine information from publicly available long- and short-read environmental metagenomes as well as whole-genome sequences to identify the original environmental hosts of dfrB, a family of genes conferring resistance to trimethoprim. Although this gene family stands

SUBMITTER: Kneis D 

PROVIDER: S-EPMC11662351 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature