Structure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.

ABSTRACT: Middle-aged and older adults with autism spectrum disorder may be susceptible to accelerated neurobiological changes in striato- and thalamo-cortical tracts due to combined effects of typical aging and existing disparities present from early neurodevelopment. Using magnetic resonance imaging, we employed diffusion-weighted imaging and automated tract-segmentation to explore striato- and thalamo-cortical tract microstructure and volume differences between autistic (n = 29) and typical comparison (n = 33) adults (40 to 70 years old). Fractional anisotropy, mean diffusivity, and tract volumes were measured for 14 striato-cortical and 12 thalamo-cortical tract bundles. Data were examined using linear regressions for group by age effects and group plus age effects, and false discovery rate corr

SUBMITTER: Cordova M 

PROVIDER: S-EPMC11662352 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature