Gastrointestinal jumbo phages possess independent synthesis and utilization systems of NAD^.

ABSTRACT:

Background

Jumbo phages, phages with genomes > 200 kbp, contain some unique genes for successful reproduction in their bacterial hosts. Due to complex and massive genomes analogous to those of small-celled bacteria, how jumbo phages complete their life cycle remains largely undefined.

Results

In this study, we assembled 668 high-quality jumbo phage genomes from over 15 terabytes (TB) of intestinal metagenomic data from 955 samples of 5 animal species (cow, sheep, pig, horse, and deer). Within them, we obtained a complete genome of 716 kbp in length, which is the largest phage genome so far reported in the gut environments. Interestingly, 174 out of the 668 jumbo phages were found to encode all genes required for the synthesis of NAD⁺ by the salvage pathway or Prei

SUBMITTER: Li C 

PROVIDER: S-EPMC11662467 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature