Prognostic value of metabolic tumor volume on [¹⁸F]FDG PET/CT in addition to the TNM classification system of locally advanced non-small cell lung cancer.

ABSTRACT:

Purpose

Staging of non-small cell lung cancer (NSCLC) is commonly based on [¹⁸F]FDG PET/CT, in particular to exclude distant metastases and guide local therapy approaches like resection and radiotherapy. Although it is hoped that PET/CT will increase the value of primary staging compared to conventional imaging, it is generally limited to the characterization of TNM. The first aim of this study was to evaluate the PET parameter metabolic tumor volume (MTV) above liver background uptake as a prognostic marker in lung cancer. The second aim was to investigate the possibility of incorporating MTV into the TNM classification system for disease prognosis in locally advanced NSCLC treated with chemoradiotherapy.

Methods

Retrospective evaluation of 235 patients with hist

SUBMITTER: Brose A 

PROVIDER: S-EPMC11662478 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature