Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study.

ABSTRACT:

Background

Congenital heart disease (CHD) is a common birth defect. Our previous studies suggest that indoor air pollution, especially total volatile organic compounds (TVOCs), may increase fetal CHD risk, whereas vitamin and folic acid (FA) supplements in early pregnancy might offer protection against CHD. However, limited research has explored whether FA or multivitamin supplementation can mitigate the effects of TVOCs exposure on CHD.

Methods

We conducted a case-control study to investigate the association between maternal nutrient supplementation, household indoor air pollutant exposure during pregnancy, and CHD in offspring. Pregnant women with 22-30 gestational weeks were recruited from two hospitals in East China between January 2016 and March 2022. A comprehensive ap

SUBMITTER: Ruan X 

PROVIDER: S-EPMC11662493 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature