Causal association between metabolites and age-related macular degeneration: a bidirectional two-sample mendelian randomization study.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly population. Accumulating evidence has revealed the possible association between metabolites and AMD. This study aimed to assess the effect of plasma metabolites on AMD and its two subtypes using a bidirectional two-sample Mendelian randomization approach.

Methods

The causality between plasma metabolites and AMD was assessed by a bidirectional two-sample Mendelian randomization (MR) analysis using the genome-wide association studies (GWAS) summary statistics of 1400 genetically determined metabolites (GDMs) and AMD. For this MR analysis, inverse variance weighted (IVW) was used as the primary method, with weighted median, MR-Egger, weighted mode, and simple mode as suppl

SUBMITTER: Liu ZY 

PROVIDER: S-EPMC11662531 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature