Near-infrared light induces neurogenesis and modulates anxiety-like behavior.

ABSTRACT:

Background

The hippocampus is associated with mood disorders, and the activation of quiescent neurogenesis has been linked to anxiolytic effects. Near-infrared (NIR) light has shown potential to improve learning and memory in human and animal models. Despite the vast amount of information regarding the effect of visible light, there is a significant gap in our understanding regarding the response of neural stem cells (NSCs) to NIR stimulation, particularly in anxiety-like behavior. The present study aimed to develop a new optical manipulation approach to stimulate hippocampal neurogenesis and understand the mechanisms underlying its anxiolytic effects.

Methods

We used 940 nm NIR (40 Hz) light exposure to stimulate hippocampal stem cells in C57BL/6 mice. The enhanced prolifer

SUBMITTER: Qi X 

PROVIDER: S-EPMC11662543 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature