Baseline echocardiographic variables as predictors of hemodynamically significant cytokine release syndrome in adults treated with CD19 CAR T-cell therapy for hematological malignancies.

ABSTRACT:

Background

CD19 CAR T-cell therapy is a novel anti-cancer treatment that has produced remarkable responses in relapsed or refractory B-cell hematological malignancies. Cytokine Release Syndrome (CRS) is a dysregulated immune response that frequently occurs after CAR T-cell infusion. It can cause cardiac dysfunction and circulatory collapse negatively impacting outcomes and survival. To endure the insults of CRS, patients are typically screened for adequate cardiac reserve before treatment. The relationship between baseline cardiac function by echocardiography and the development of moderate to severe presentations of CRS is unclear.

Methods

This study aimed to identify baseline echocardiographic variables that can predict the development of hemodynamically significant CRS (C

SUBMITTER: Daryanani AE 

PROVIDER: S-EPMC11662545 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature