L-Arginine supplementation as mitochondrial therapy in diabetic cardiomyopathy.

ABSTRACT: In patients with type II diabetes, the development of diabetic cardiomyopathy (DC) is associated with a high risk of mortality. Left ventricular hypertrophy, diastolic dysfunction, and exercise intolerance are the first signs of DC. The underlying mechanisms are not fully elucidated, and there is an urgent need for specific biomarkers and molecular targets for early diagnosis and treatment. Mitochondrial alterations play a key role in the development of DC, and microRNAs regulating mitochondrial function are emerging as potential biomarkers of metabolic stress in DC. L-Arginine (Arg) supplementation has been shown to be an effective strategy for improving mitochondrial function and energetics, with a significant impact on physical performance. The aim of the current study was to evaluate t

SUBMITTER: Fiordelisi A 

PROVIDER: S-EPMC11662564 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature