Identification of D842V mutation in gastrointestinal stromal tumors based on CT radiomics: a multi-center study.

ABSTRACT:

Background

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Recent advent of tyrosine kinase inhibitors (TKIs) has significantly improved the prognosis of GIST patients. However, responses to TKI therapy can vary depending on the specific gene mutation. D842V, which is the most common mutation in platelet-derived growth factor receptor alpha exon 18, shows no response to imatinib and sunitinib. Radiomics features based on venous-phase contrast-enhanced computed tomography (CECT) have shown potential in non-invasive prediction of GIST genotypes. This study sought to determine whether radiomics features could help distinguish GISTs with D842V mutations.

Methods

A total of 872 pathologically confirmed GIST patients wi

SUBMITTER: Xie Z 

PROVIDER: S-EPMC11662607 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature