Limbic system synaptic dysfunctions associated with prion disease onset.

ABSTRACT: Misfolding of normal prion protein (PrP^C) to pathological isoforms (prions) causes prion diseases (PrDs) with clinical manifestations including cognitive decline and mood-related behavioral changes. Cognition and mood are linked to the neurophysiology of the limbic system. Little is known about how the disease affects the synaptic activity in brain parts associated with this system. We hypothesize that the dysfunction of synaptic transmission in the limbic regions correlates with the onset of reduced cognition and behavioral deficits. Here, we studied how prion infection in mice disrupts the synaptic function in three limbic regions, the hippocampus, hypothalamus, and amygdala, at a pre-clinical stage (mid-incubation period) and early clinical onset. PrD caused calcium flux dysr

SUBMITTER: Foliaki ST 

PROVIDER: S-EPMC11662616 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature