Circular oligomeric particles formed by Ros/MucR family members mediate DNA organization in α-proteobacteria.

ABSTRACT: The transcriptional regulator MucR from Brucella species controls the expression of many genes, including those involved in virulence, by binding AT-rich DNA regions. MucR and its homologs belong to the Ros/MucR family, whose members occur in α-proteobacteria. MucR is a recent addition to the family of histone-like nucleoid structuring (H-NS) proteins. Indeed, despite the lack of sequence homology, MucR bears many functional similarities with H-NS and H-NS-like proteins, structuring the bacterial genome and acting as global regulators of transcription. Here we present an integrated cryogenic electron microscopy (cryo-EM), nuclear magnetic resonance, modeling and biochemical study shedding light on the functional architecture of MucR from Brucella abortus and its homolog Ml5 from Mesorhizob

SUBMITTER: Chaves-Sanjuan A 

PROVIDER: S-EPMC11662661 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature