Proteomic profiling reveals the significance of lipid metabolism in small cell lung cancer recurrence and metastasis.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is a lethal and recalcitrant malignancy with early metastases. However, the molecular and cellular mechanisms underlying its aggressive characteristics remain relatively elusive.

Methods

In this study, we conducted a comprehensive proteomic analysis of 90 primary tumors, 15 patient-matched lymph node metastatic tumors, and 15 brain metastatic tumors derived from a cohort of 105 SCLC patients. The potential mechanism for SCLC metastasis was investigated based on the variety of protein expression profiles.

Results

Primary tumors were divided into two categories according to the their different protein expression profiles, using metastatic tumors as reference. Proteomic comparisons across different groups revealed that lipid metab

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11662706 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature